Head of Lipid Nanoparticle Core

Fondazione Telethon (FT) is a leading biomedical charity committed to advancing research into tangible therapeutic options for people living with rare genetic diseases. Through its affiliated research institutes – TIGEM (Naples) and SR-TIGET (Milan) – FT has established an internationally recognized track record in the development of novel gene therapy approaches, including

AAV-

and

Lentiviral Vector-mediated gene transfer,

and their clinical application, with more than 170 patients successfully treated to date.

Furthermore, FT has pioneered the development and application of genome

and

epigenome editing

approaches for precise gene correction and gene silencing, and it remains at the forefront of these technologies. To support the preclinical advancement of these cutting‑edge approaches, FT is now expanding its capabilities in the

non-viral gene delivery space , aiming at establishing a cross-institute Core facility dedicated to the production and characterization of Lipid Nanoparticles (LNPs).

Le informazioni riportate di seguito illustrano i requisiti del ruolo, l'esperienza richiesta ai candidati e le qualifiche associate.

THE POSITION FT is seeking an experienced and forward-thinking scientist to serve as Head of Lipid Nanoparticle Core, leading an integrated initiative across TIGEM and SR-TIGET. The position offers a unique opportunity to shape a strategic technology platform within the globally recognized Fondazione Telethon R&D ecosystem. The successful candidate will design, implement, and manage the Core, supporting internal research groups and translational programs. The position is based at SR-TIGET (Milan) and requires regular travel between the two sites.

Key Responsibilities Establish and lead the Lipid Nanoparticle Core, ensuring alignment with the strategic priorities of the two Institutes Define and implement the operational strategy, including workflows, SOPs, quality standards and resource allocation, while ensuring harmonized processes across both Institutes Recruit, mentor, and supervise dedicated Core staff Serve as the primary interface with internal units (including research groups and development functions), and external stakeholders (including academic partners, industry collaborators, and technology providers) Drive innovation in the LNP space and related enabling technologies. Contribute to grant writing and external funding applications.

Qualifications PhD in Chemistry or a closely related discipline (e.g., Chemical Engineering, Pharmaceutical Sciences, Materials Science). 5+ years of post‑PhD experience in relevant scientific fields Documented track record in LNP design, production, and characterization; experience with LNP functionalization and/or CMC is considered a plus. Documented experience with in vivo applications of LNPs Familiarity with quality-driven workflows; experience in industry, biotech, or GLP-oriented environments is an advantage. Proven leadership capabilities, including team building and the ability to drive cross-functional initiatives. Excellent command of written and spoken English. Outstanding communication and organizational skills, with the ability to manage stakeholders and effectively prioritize activities.

WHAT WE OFFER Welfare

scheme Assistance with applying for tax benefits , including attractive income tax reductions for candidates relocating to Italy for the first time or returning after living abroad. xpavfwm Moving support , including relocation allowance, assistance with bureaucratic procedures (e.g., visa, residence permit, healthcare registration), and Italian language training Work-life balance solutions

(flexible working time, remote working, 5-month fully paid maternity leave, parental leave, on campus nursery with discounted rates) Access to National Health System

providing residents with free or reduced-cost healthcare (including access to general practitioners, treatment at public hospitals, subsidized medicines, ambulance services) and access with discounted rates to private specialist care at San Raffaele Hospital CCNL Commercio;

Salary Range:

4 €

Fondazione Telethon is an Equal Opportunity Employer committed to increasing the diversity of its staff and provides employment opportunities regardless of individual’s age, color, disability, gender, national origin, religion, or sexual orientation.